The game is the final installment in French-Bread's Melty Blood series of fighting games, which features characters from Type-Moon's Tsukihime visual novel, as well as original characters.
The game also features the character Ryougi Shiki from Type-Moon's The Garden of Sinners novel and anime film series. The series began as a dōjin (fan) game by French Bread on the PC in 2002, with a story mode serving as a sequel to Tsukihime. The franchise has since had multiple releases in arcades, on the PlayStation 2, and on the PC.
Melty Blood: Actress Again - Current Code originally received a PC release in 2011, but only when bundled with the limited-edition Blu-ray Disc volume of the Carnival Phantasm 3rd Season anime. The game takes place one year after the "Tatari" incident that "left Misaki Town scarred."